A gain-of-function PIK3CD variant, R512W, impairs T cell function through polyamine-dependent metabolic dysregulation

Kyoko Kiyota, Hiroshi Shiraishi, Shiho Ohno, Yasuhiro Soga, Nobuyuki Shimizu, Hiroyuki Yatsuka, Masanori Inoue, Takashi Takeno, Wang Honxia, Adiana Mutamsari Witaningrum, Reiko Hanada, Yoshiki Yamaguchi, Kenji Ihara, Toshikatsu Hanada

BBRC, Volume 778, 8 September 2025, 152378